Objective To investigate the factors influencing the bonding strength of the coating and the substrate to figure out a method to increase the lifetime of Artificial Mechanical Heart Valves. Methods The interfacial adhesive strength of pyrolytic carbon-graphite for Artificial Mechanical Heart Valves was tested by the improved shear test. The finite element analysis software ANSYS was used to complete a three-dimensional analysis of interfacial shear stress of pyrolytic carbon-graphite, and the results were compared with the experimental results so that the accuracy of ANSYS analysis could be verified. ANSYS was used to analyze the differences of interfacial adhesive strength with different thicknesses of coating and elasticity modulus. Results The average interfacial adhesive strength was 5. 535 MPa according to shear test, while the value was 5. 98 MPa as calculated by ANSYS. The interfacial strength decreased as the thickness of Pyrolytic coating increased, and increased as the coating elastic modulus increased, but the elastic modulus value was not the higher the better, and there should be a proper value. Conclusion The ANSYS analysis was accurate. The Pyrolytic carbon coating should be as thin as possible and the elasticity modulus should be larger than that of Graphite.