Objective To reveal the influence of nanometer powders on the high temperature protection performance of laser cladding . Methods Using NiCoCrAlY alloy powder as cladding material and with addition of SiC nanometer powders, laser cladding of SiC nanometer powders was conducted on the surface of GH4037 alloy to reinforce the Ni-Based alloy coating. The microstructure of the cladding layer and the interface region was analyzed, and the high temperature oxidation resistance was tested at 1070 ℃ .Results The results showed that the microstructure of laser cladding coating with the addition of SiC nanometer powders was obviously refined, without any obvious flaws in its laser cladding interface region, its high-temperature oxidation rate was much lower than that of the layer without adding nanometer powders, its oxide film was dense and its anti-stripping capability was significantly enhanced. Conclusion The microstructure of the Ni-Based alloy laser cladding was obviously refined by adding appropriate amount of SiC nanometer powders, which could also inhibit crack formation in the interface region. The high temperature oxidation resistance of the laser cladding was significantly improved.