Objective In order to study the effects of nanoparticles on the hot corrosion resistance of Ni-based alloys cladding. Methods Nano-Al₂O₃ particles reinforced NiCoCrAlY alloy cladding was prepared using the tabletting preset laser cladding process. The microstructure and interface cracks of cladding layer were analyzed, and high temperature corrosion was performed in the 1000 益 molten salt . Results The results showed that the laser cladding interface region prepared with addition of Al₂O₃ particles did not show obvious flaws, compared to the layer prepared without addition of nanoparticles, its hot corrosion weight loss rate was much lower, its corrosion surface did not show serious uplift and flake, and its corrosion depth was low. Conclusion Addition of appropriate amount of nano-Al₂O₃ particles had an inhibitory effect on the formation of cracks in the NiCoCrAlY alloy laser cladding interface region. And the high temperature corrosion resistance of the laser cladding layer was significantly improved.