Hydrogen embrittlement occurs in a wide range of metal materials, and its invisibility and time lag often lead to catastrophic accidents, restricting the application of metal materials in extreme working conditions. Multi- principal-element alloys or high-entropy alloys have broken through the traditional alloy design concept and become a hot spot in the field of new metal materials. It is found that some high-entropy alloys or multi-principal-element alloys possess excellent properties beyond those of traditional alloys or are comparable to traditional alloys, such as ultra-high strength and ductility matching, heat resistance, corrosion resistance, and hydrogen embrittlement resistance, which are expected to be used in extreme working conditions. The work aims to introduce the theoretical mechanisms of hydrogen embrittlement and review the research progress of hydrogen-embrittlement-resistant multi-principal-element alloys.