Medical interventional guidewires are widely used in various interventional procedures and are commonly used medical devices in percutaneous transluminal coronary angioplasty (PTCA) and percutaneous transluminal angioplasty (PTA). Although the size of the interventional guidewire is quite small in the whole medical device system, it is used in a large amount in clinical practice. With the rapid development of the medical device industry, medical interventional guidewires are becoming more and more common in clinical applications. The coating on the surface of medical interventional guidewires works as an important support for application promotion and function expansion. The attachment of hydrophilic or hydrophobic coating on the surface of guidewires has received extensive attention from researchers. The addition of hydrophilic or hydrophobic coatings to the surface of medical interventional guidewires can reduce tissue friction and tissue damage in clinical applications, effectively improve the passage, antimicrobial and biocompatibility of the guidewires, and reduce inflammation. The coating may peel off from the surface due to weak bonding, leading to adverse events. In recent years, there have been successive reports focusing on coating shedding, the hazards of which include residual coating debris in patients, local tissue reactions and vascular thrombosis, and can even lead to serious adverse events including embolic stroke, tissue cell necrosis and death, so a more comprehensive and rational means of surface modification is necessary to make the guide wire surface coating with good hydrophilic or hydrophobic premise, not only with good adhesion and the surface modification must be carried out in a more comprehensive manner, so that the surface coating of the guidewire not only has good adhesion and solidity, but also has good biocompatibility and antibacterial and antibacterial properties.