Superhydrophobic surfaces have attracted great attention from researchers in China and abroad due to their low adhesion, self-cleaning, anti-corrosion, drag reduction, and good anti-icing properties. The work aims to adopt a novel femtosecond laser composite dealloying method to prepare superhydrophobic self-cleaning Ti6Al4V alloy surfaces. Firstly, 800# sandpaper was used for grinding, and after ultrasonic cleaning and drying, the micron-scale structure was pre-prepared on the surface of Ti6Al4V alloy via femtosecond laser in a 90° vertical cross-scanning manner. The laser processing parameters were as follows:laser fluence 0.30 J/cm2, repetition frequency 200 kHz, scanning speed 200 mm/s, scanning spacing 20 μm, and 6 times of repetition. Then, the pre-prepared surface samples were placed in 1.0 mol/L sodium hydroxide solution, the appropriate voltage was selected, and electrochemical dealloying was carried out in the state of ultrasonic water bath at temperature of 40 ℃ for 5 h to prepare the micro-nano composite structure. Next, the surface of the de-alloyed sample was modified with fluoroalkyl silanes and stored at 100 ℃ for 30 min in a vacuum incubator to obtain a micro-nano superhydrophobic titanium alloy surface.