Polyether ether ketone (PEEK) has the advantages of high mechanical strength, excellent chemical stability, and transparency to diagnostic X-rays, and its density and elasticity is closer to bones compared to metals. PEEK is widely used in biomedical fields such as trauma, spine, and joints. However, PEEK is a bioinert material with insufficient osteointegration, which limits the development and application in bone repair and replacement to a certain extent. Plasma spraying (PS) technology is an important surface coating modification technology to solve the problem of bone integration of PEEK materials due to its simple process, economy, and high adhesive strength of the coatings. Firstly, this paper briefly describes the coating deposition mechanism of PS process, then titanium (Ti) and hydroxyapatite (HA) coatings manufactured by PS are introduced respectively; Secondly, based on the different spraying processes and spraying parameters, the latest research progress of plasma sprayed PEEK-based coatings on mechanical properties such as bonding strength in recent years is introduced in detail. The effects of PS process on the initial properties of PEEK substrate, such as mechanical strength, fatigue strength, thermal properties and chemical degradation are summarized and evaluated; The latest research progress of plasma sprayed PEEK-based coatings on biological properties in vitro and in vivo is also introduced in detail; Finally, the clinical application of plasma sprayed PEEK is prospected to provide theoretical guidance for the design of new PEEK-based biomaterials in the future.