To prepare an environment-friendly protective coating with marine antifouling and drag reduction functions, a novel long-chain linear silicone molecules were intelligently integrated in polymer resin, and the self-lubricating coating was prepared compounded with certain inorganic pigment. Foundational properties of coating, including hardness, impact resistance, adhesion, viscoelasticity, surface roughness, surface wettability and self-lubricating properties, were evaluated respectively. Moreover, the antifouling performance of the coating was characterized in terms of different fouling scales, from protein, algae to marine organism, and the drag reduction property of the coating was also measured by a rheometer. The results indicated that the coating hardness descended from 2H to 4B, the adhesion grade changed from 0 grade to 2 grade and the impact resistance decreased slightly with the increase of self-lubricating organic silicone component in the coating, while the contact angle increased from 65° to 92°. Importantly, the self-lubricating properties, antifouling and drag reduction performance of the coating were significantly enhanced with the increase of organic silicon monomer, which were attributed to the minimal surface roughness (less than 500 nm). The friction coefficient under the dry grinding condition was also expected to decreased from 0.119 to 0.075. Besides, when the mass content of organic silicon component was more than 20%, the 97% antifouling ratio of marine algae and 10% drag reduction efficiency were achieved. Finally, the marine field test further proved the excellent antifouling and comprehensive performance of the coating. This research provided a method of preparing silicon coating with both antifouling and drag reduction functions through chemically integrating linear long-chain silicone component in the coating binding resin. Giving their environmental-friendly character, stable performances and facile preparation method, the as-prepared coating had a bright application prospect in the field of marine equipment protection.