The work aims to construct a friction coefficient model and a wear model of MoS2 film, and predict the wear volume. The effect law of normal load and sliding velocity on the friction coefficient of MoS2 film was studied by a ball-on-disk tribometer. The maximum contact pressure was between 441.08 and 1393.82 MPa, and the sliding velocity was from 0.05 to 0.628 m/s. The wear morphology of MoS2 film was characterized respectively by field emission scanning electron microscope (SEM) and white light confocal microscope. Based on Hertz contact theory, the mathematical model of friction coefficient, normal load and sliding velocity of MoS2 film was proposed. The maximum relative error between the predicted results and the measured results was 12.02%, and the relative error of other results was less than 10%. From the perspective of friction dissipation energy, it was found that there was a linear relationship between the wear volume and friction energy consumption of MoS2 film. Then, a wear model of MoS2 film was established combined with the new friction coefficient model. This wear model was a function of normal load, sliding velocity and friction time and the average absolute value of relative error of the wear model was 10.81%. Compared with the results of Archard model, the relative error of the new wear model was smaller. The wear mechanism of MoS2 film was analyzed to discuss the causes of errors in wear model. The predicted results of the friction coefficient model and wear model are in good agreement with the measured results. The wear model can accurately predict the wear of MoS2 film, which has important engineering application value.