Long-life metal oxide anodes with excellent chlorine evolution performance were investigated by the introduction of TNTs (TiO2 nanotube array) interlayer and the composition adjustment. TiO2 nanotube arrays with good conductivity and chemical stability were fabricated by in-situ growth on titanium matrix via anodic oxidation and heat treatment, and then RuIrTa oxide were loaded on the TNTs by coating and thermal decomposition process. The microstructure, composition and crystal structure of the electrodes were characterized by field emission scanning electron microscopy (FESEM) and X-ray diffractometry (XRD). The chlorine evolution activity and stability of electrodes were studied by cyclic voltammetry curve and accelerated corrosion test. The influence of composition and coating amount on the electrode performance were emphatic investigated. The degradation efficiency of chloride ions in water by the prepared anode was also studied. The results show that the TNTs interlayer can effectively reduce the number of cracks and the crack gap of coatings. The accelerating life time of RuIrTa electrodes with TNTs interlayer is much longer than that of the electrode without interlayer. The introduction of tantalum into the coating can further improve the electrode stability, but reduce its electrochemical activity. In addition, the coating amount is a key factor influencing the uniformity of coatings. Excess amount of coating will lead to low utilization of active ingredients and coating cracking. The composite electrode with coating amount of 4.5 g/m2 and Ru∶Ir∶Ta=3∶7∶1 has better comprehensive performance. It not only has high chlorine evolution activity, but also has better stability, which can be used for the electrolysis of chlorine ions with low content in water. Therefore, we can conclude that the RuIrTa oxide anode with the TNTs intermediate layer has excellent stability and electrochemical activity.