This paper aims to improve the wear resistance and corrosion resistance of cast iron surface. The cladding layer of Hastelloy C276 was prepared on the surface of cast iron by laser cladding. The microstructure, chemical composition and phase constitution were studied by scanning electron microscope (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The friction and wear properties and corrosion resistance of the substrate and cladding layer were tested by friction-wear test machine and electrochemical workstation. It was found that precipitated pores existed in the cladding layer, but no cracks. Under the action of laser high temperature heat source, the alloying elements in the cladding layer diffuse into the cast iron substrate, and the transition is smooth, forming a good metallurgical bonding. Martensite and ledeburite are formed at the interface. The main phase of the cladding layer was composed of γ-Ni and carbides such as Ni6Mo6C and M6C(Ni3Mo3C, Ni2W4C). From the bottom to the top of the cladding layer, planar crystals, cellular crystals, columnar crystals, developed dendrites or cellular dendrites and a few equiaxed dendrites were formed in this order. The average microhardness of the cladding layer was 370HV0.2, the average friction coefficient was 0.28, and the wear amount was 0.081 g for 1 h. The self-corrosion potential of the cladding layer was –0.32 V, and the self-corrosion current density was 8.51×10–7 A/cm2. The wear resistance of the substrate was poor, and the corrosion tendency was greater. The average microhardness of the cladding layer was 180HV0.2, and its average friction coefficient was 0.34, and the wear amount was 0.318 g for 1 h. The self-corrosion potential of the cladding layer was –0.79 V, and self-corrosion current density was 3.31×10–6 A/cm2. The C276 Hastelloy coating prepared by laser cladding on the surface of cast iron has good molding effect, and the wear resistance and corrosion resistance are significantly improved.