The paper reasonably selects the counterpart to shut down the friction and wear of the Ni3Al-based coating in a wide temperature range. The WC-Co and 316L were used as counterparts, respectively, and the effect of the counterparts on the lubrication and wear mechanism of Ni3Al-based coating within 25~ 800 ℃ was investigated. The hardness of the counterparts at different temperatures were tested by a high-temperature hardness tester. The morphology and composition of the worn surface of coating, the counterpart worn surface and debris were observed and analyzed by a scanning electron microscope with an energy spectrometer. The composition of the worn surface and worn surface of the counterparts were characterized by a Raman scattering instrument. The results showed that the friction coefficient of the two friction pairs had a consistent change law with the increase of temperature within 25~800 ℃. When sliding against WC-Co, the coating had lower wear rate at all temperature, and the wear rate decreased with the increasing of temperature. When sliding against 316L at 25~200 ℃, the wear mechanism of the Ni3Al/316L friction pairs was dominated by adhesive wear and abrasive wear. While the coating happened plastic deformation under high contact stress, which inhibited the precipitation of lubricating phase Ag and the peeling of coating, making it had higher friction coefficient and lower wear rate than the former. At 400 ℃, the frictional heat generated under the high contact stress promoted slight oxidation to form NiO and NiCr2O4, which made its anti-friction performance better than Ni3Al/316L friction pairs. Within 600~800 ℃, the wear mechanism of the Ni3Al/316L friction pairs changed from severe adhesive wear to oxidative wear, while the Ni3Al/WC-Co friction pairs transformed from oxidative wear and peeling wear to oxidative wear. Within 800 ℃, the friction and wear of Ni3Al/316L friction pairs occured between the smooth lubrication film and rough transfer film, while the Ni3Al/WC-Co friction pairs occurred between the smooth lubrication film. Within 25~800 ℃, the coating had good anti-friction performance when sliding against 316L and WC-Co, and it had better wear resistance when sliding against WC-Co.