This paper aims to achieve the medical degradation controllability by optimizing the corrosion resistance of pure zinc through controlling the technological parameters of micro-arc oxidation. By setting different technological parameters such as positive voltage, reaction time, duty cycle, negative voltage and subsection treatment, a micro-arc oxidation (MAO) film was formed on the surface of pure zinc. The surface morphology and section thickness of the MAO film were observed by scanning electron microscopy (SEM). Elements and phase structure of the MAO film were analyzed by energy disperse spectroscopy (EDS) and X-ray diffraction (XRD). The wettability and corrosion resistance were analyzed by surface tension meter and electrochemical polarization curve. The results show that the porosity and corrosion rate of the film could be effectively reduced by increasing the positive voltage, reducing the duty cycle and controlling the treatment time and negative voltage, the micro-arc oxidation treatment can increase the hydrophilicity of the sample surface, and the segmented treatment has a significant effect on wettability and corrosion resistance. When the positive voltage is 300 V, the duty cycle is 10%, the reaction time is 5 min, and the negative voltage is –100 V, the MAO films with strong hydrophilicity and good corrosion resistance can be formed. The film has a porosity of 10.95%, a film thickness of 5.29 μm and a corrosion current density of 5.74×10–6 A/cm2. Therefore, it is concluded that the micro-arc oxidation treatment can obviously enhance the hydrophilicity of pure zinc surface, and the film structure can be changed by adjusting different technological parameters of the micro-arc oxidation, so as to optimize its wettability and corrosion resistance.