The work aims to study the effect of reticulate micro-texture on the friction and wear properties of 316L stainless steel microwires, thereby providing a reference idea for improving the service life of metal rubber. The LQL-F20A laser marking machine was used to process reticulate micro-textures with different depths and pitches on the surface of 316L stainless steel microwires with a diameter of 0.4 mm. The Leica-DM6A microsystem was used to measure the texture depth and width. The reciprocating small-stroke fretting friction and wear test machine was used to conduct the friction and wear test. The frictional coefficients and wear depths of the stainless steel microwires under different loads were measured and recorded. The surface morphology of stainless steel microwires before and after friction and wear was observed and compared with a scanning electron microscope. The test result showed that under the same conditions, the surface frictional coefficient and wear depth of the reticulated- textured specimens were reduced by 28% and 72% compared with the untextured specimens. The frictional coefficient and wear depth of the specimens with a texture depth of 25 μm were reduced by 0.16 and 9 μm compared with the specimens with a texture depth of 11 μm, respectively. The frictional coefficients wear depths of the specimens with different texture pitches were very close. The wear depth differed little. The frictional coefficient of the specimens did not change much under different loads, but the wear depth increased with the increasing load. The reticulated-textured surface of the stainless steel microwires can significantly improve the friction and wear properties. The depth of the texture is an important factor affecting the wear resistance of the stainless steel microwires. The pitch and depth of the texture have a subtle synergistic effect on the friction and wear properties of stainless steel microwires. The wear depth of the microwire is positively correlated with the external load.