The work aims to prepare ceramic particle reinforced Ni-based composite coating on the Ti6Al4V alloy surface by argon arc cladding technique to improve the friction and wear resistance of alloy. Ti, BN and Ni60A powders were mixed by milling and ceramic particle reinforced Ni-based composite coating was in situ fabricated on the Ti6Al4V alloy surface by argon arc cladding technique. The composition, morphology, size, distribution and structural characteristics of ceramic particles in cladding coating were analyzed by X-ray diffraction analyzer (XRD), Energy Dispersion Spectrum (EDS), Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). Microhardness and wear resistance of the cladding coating were examined by Vickers hardness tester and ring-block friction and wear tester and the morphologies were studied by SEM. The main phases of cladding coating contained TiN, TiNi, TiB, TiB2 and α-Ti. The ceramic particle particles synthesized in situ were uniformly distributed in cladding coating. The morphologies of TiN, TiB and TiB2 were in the form of grain, needle and rod, respectively. The surface microhardness of cladding coating reached 1210~1250HV0.5. Under the same wear condition, the wear loss of TC4 alloy matrix and cladding coating was 34.23 mg and 4.86 mg, respectively, which was obviously reduced. There was no adhesive trace on the worn surface of the cladding coating, and the main wear mechanism of the cladding coating was abrasive wear. Compared with the Ti6Al4V alloy substrate, the microhardness of the cladding coating is improved by 4 times. The wear resistance of titanium alloy can be effectively improved by multi-phase ceramic particles.