To investigate the effect of mesoporous molecular sieve loaded with corrosion inhibitor on the corrosion resistance of epoxy coating, in this paper, corrosion inhibition particles were obtained by adding organic corrosion inhibitor C12H22ZnO14 and inorganic corrosion inhibitor Ce(NO3)3 respectively to modify mesoporous molecular sieve MCM-41, and then the obtained corrosion inhibition particles were mixed with the epoxy coating to prepare the composite epoxy coating with self-repairing function. The corrosion resistance of composite epoxy coatings was evaluated by neutral salt spray test, electrochemical impedance spectroscopy (EIS) and local electrochemical impedance spectroscopy (LEIS), and the surface morphology after corrosion was observed by optical microscope. When the corrosion inhibitor content is 5%, the coating resistance of EV from 9.93×104 Ω fell to 3.71×104 Ω after immersing for 50 d，while cerium modified composite coating resistance from 2.33×105 Ω fell to 1.06×105 Ω, indicating that change tendency is more stable. organic zinc salt modified composite coating foaming phenomenon has been obviously improved after immersing. When the corrosion inhibitor content is 10%, the content of microporous defects in the composite coating increases, and meanwhile causes the change of osmotic pressure, which makes the corrosive medium penetrate more easily to the surface of the metal substrate and accelerates corrosion. In the coating with defects, the measured impedance values around the defects of the two kinds of modified coatings tended to decrease first and then increase, and self-repairing phenomena occurred in both coatings. Above all, the addition of mesoporous molecular sieve particles with appropriate amount of corrosion inhibitor can effectively improve the anti-corrosion performance of epoxy coating. Zn2+/Ce3+ could form insoluble compounds at the defects area resulting the limit of corrosion reaction, which is the main reason for improving the anti-corrosion ability of epoxy coating.