The work aims to study the effect of temperature on friction and wear properties of TiB2-50wt.%Ni coatings. TiB2-50Ni ceramics-metal composite coatings were prepared on 304 stainless steel substrate by high velocity oxygen flame spraying (HVOF) with “shell and core type” Ni coated TiB2 powder. Microstructure and phase structure of HVOF coatings were characterized by SEM and XRD, respectively. Friction and wear properties of TiB2-50Ni composite coating and 304 stainless steel at high temperature were systematically investigated. The cross section of HVOF composite coating showed obvious laminated structure, and its thickness, porosity, micro-hardness, average surface roughness and bond strength were 300.8 μm, 2.3%, 766.1HV, 2.3 μm and 22.6 MPa, respectively. The friction coefficient of 304 stainless steel substrate fluctuated greatly with wear rate increasing sharply as the environment temperature rises. However, the friction coefficient and wear rate of HVOF TiB2-50Ni coating fluctuated slightly. The wear rate of HVOF coating at 600 ℃ was (2.73±0.01)×10–5 mm3/(N?m), about a quarter of the wear rate of 304 stainless steel substrate of (11.07±0.01)×10–5 mm3/(N?m). The wear mechanisms of TiB2-50Ni coatings at high temperature were abrasive wear, adhesion wear and oxidation wear. The HVOF TiB2-50Ni composite coating has excellent high temperature friction and wear properties with least influence from increasing environment temperature.