The work aims to investigate the effects of laser irradiation temperature and particle impact velocity on the interfacial bonding characteristics of Ti-6Al-4V particles in the Supersonic Laser Deposition (SLD), and verify the numerical simulation results by experiments. Based on Johnson cook material model, coupled Euler Lagrange Model and Lagrange model were used to simulate the impact behavior of single and multiple Ti-6Al-4V particles by ABAQUS 2017 software, and the simulation results were further verified via supersonic laser deposition technology. The interfacial bonding characteristics of the coating were observed and analyzed by Scanning Electron Microscopy (SEM) and Optical Microscope (OM). The simulation results of the temperature field for single particle impact showed that the interfacial temperature of particles increased with the increase of impact velocity when the laser irradiation temperature was 1073 K. When the impact velocity was 800 m/s and 900 m/s, the local maximum temperature of particles and matrix was 1876.7 K and 1874.8 K respectively, and micro melting occurred at the interface. When the impact velocity was 800 m/s, the compression rate of particles was 34.3%, the flattening rate was 1.27, the effective plastic strain was 2.6, and the crater depth of matrix was 7.88 μm. Therefore, a good interfacial bonding was achieved under such conditions. It was found by simulating the temperature field of multi-particles impact that when the impact velocity was 800 m/s, the pores gradually decreased with the increase of laser irradiation temperature. When the laser irradiation temperature was 1073 K, the temperature of particle impact interface reached 3463.7 K, but the temperature inside the particle did not reach the melting point and remained at 1073~1676.8 K. With the increase of laser power, the porosity of titanium alloy coating decreased to 0.67% (SLD 700 W), which was 12 times lower than that of CS coating (8.31%). The thermal energy of laser irradiation makes the interfacial temperature between particles and matrix as well as the interfacial temperature between particles reach the melting point of materials, and realize the micro-melting on the surface of particles, thus resulting in metallurgical bonding. There are obvious pores between the particles and the matrix in the cold spray coating, but in the Ti-6Al-4V coating by supersonic laser deposition, the interface between the particles and the matrix is well bonded. The experimental results are in good agreement with the numerical simulation results.