The work aims to fabricate a water resistant hydrophilic anti-fog coating. Polyether modified POSS (POSS-SH6- PEGMA2) was prepared by synthesizing polyether polyhedral oligosilsesquioxanes through thiol-ene click chemistry. The structure of the reaction products were characterized by FT-IR and 1H-NMR. Then, the reaction products were mixed with hydrophilic UV resin. The mixture was coated and UV-cured on a cleaned polycarbonate sheet to form a hydrophilic anti-fog coating with high water resistance. The X-ray photoelectron spectroscopy was used to analyze surface elements of the coating. The 3d optical microscope was used to analyze the surface topography of coatings. The contact angle measurement was used to characterize the hydrophilic property of coatings. The water resistance and anti-fog performance were also evaluated. The XPS results indicated that POSS migrated in the coating and enriched on the surface. With the help of the 3D optical microscope, a series of different micro structures were found on the surface, indicating that the surface roughness was increased. The hydrophilic and anti-fog properties and water resistance of the coating were improved with the increase of the content of POSS-SH6-PEGMA2 within a certain range, and the coating had the best water resistance (the water absorption rate was 7.3%), hydrophilic property (the water contact angle was 7.41°±2.35°) and anti-fog performance when the content of POSS-SH6-PEGMA2 was 55% (9.71% POSS). Adding polyether modified POSS into PEGDMA coating (the content of POSS-SH6-PEGMA2 is 55%) can obtain a hydrophilic and anti-fog coating with high water resistance.