The work aims to solve the problem of high susceptibility of 7050 aluminum alloy to hydrogen induced delayed cracking in humid air, so as to extend its service life. Micro-arc oxidation (MAO) coating was formed on the surface of 7050 aluminum alloy by micro-arc oxidation process to study the effect of MAO coating on hydrogen induced local plastic deformation in high-strength aluminum alloy. Through the double-cantilever beam (DCB) sample constant displacement test, the effect of the MAO coating on the stress corrosion susceptibility of 7050 aluminum alloy was evaluated, and the crack propagation was in-situ observed and recorded by metallographic microscope and reading microscope. The morphology of the fracture was observed by a scanning electron microscope (SEM), and the hydrogen content was analyzed with a hydrogen analyzer. After MAO treatment, the behavior of hydrogen induced local plastic deformation in 7050 aluminum alloy decreased significantly. The stress corrosion cracking threshold KISCC of the sample with MAO coating was 23.340 MPa?m1/2, while the KISCC of the sample without MAO coating was 16.934 MPa?m1/2. The crack growth rate of the MAO coating sample was 6.378×10–6 m/s, while that of the sample without MAO coating was 1.3612×10–5 m/s. Meanwhile, the hydrogen content in the DCB sample with MAO coating reduced from 0.281×10–6 to 0.163×10–6. The MAO coating can reduce the hydrogen content at the crack tip of aluminum alloy, thus restraining the hydrogen induced local plastic deformation.