The work aims to improve the wear resistance and hydrophobicity of the polyurethane coating material. Hydrophobic fluorinated polyurethane (FPU) coating was prepared with perfluorooctylethyl alcohol (TEOH-8) and diphenylmethane diisocyanate (MDI) as raw materials. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), abrasion test and SEM were adopted to analyze the functional groups in the coating and the glass transition temperatures of soft and hard segments of fluorinated polyurethane and characterize the wear resistance and surface microstructure of the coating. ATR-FTIR showed that FPU did not contain —CH2OH group. The result of differential scanning calorimetry (DSC) indicated that when FPU elastic coating was subject to erosion, with the increase of the external force, the Tg(HS) of hard segment decreased, the crystallinity of hard phase increased, the tensile strength of the hard phase increased, and the wear resistance of the coating also increased. The abrasion test showed that the actual amount of FPU coating was 0.9313×10-3 kg, less than the guaranteed cavitation amount according to the running time and achieving the standard of the guaranteed cavitation amount, and the wear resistance increased by 44.68% relative to alloy. Scanning electron microscopy and energy spectrum analysis showed that scratches appeared on the worn surface, but the C—F chain with higher bond energy near the surface had high strength and water resistance, preventing the wear from spreading deeper into the coating. Hydrophobic FPU have better water resistance and abrasion resistance, and can be used to protect the underwater parts.