The work aims to investigate the feasibility of ultrasonic vibration hybrid lapping for optical glass, and seek the optimal combination of process parameters by ultrasonic vibration lapping through response surface method. Ultrasonic vibration, peristaltic pump and rotating table are added to the traditional lapping device to form an ultrasonic vibration hybrid lapping device. The addition of axial ultrasonic high frequency vibration improves the lapping efficiency; adding a rotating table to improve the lapping uniformity; adding a peristaltic pump facilitates circulation and renewal of the slurry. The response surface method is used to optimize the three variables of spindle speed, vibration frequency and machining gap in the ultrasonic vibration hybrid lapping process, and the experimental research can be carried out to obtain the correlation degree between the two variables, and the most influential factors in the lapping are obtained. The optimal process parameters of ultrasonic vibration hybrid lapping after response surface optimization are: spindle speed 1000 r/min, machining gap 0.4 mm, vibration frequency 12 kHz, spindle speed and clearance parameters, which have a great influence on the surface lapping process. After 25 min lapping, the conventional lapping method without ultrasonic vibration is used to grind, and the surface roughness Ra decreases from 0.3 μm to 0.1 μm. After the ultrasonic vibration hybrid lapping, the surface roughness Ra decreases from 0.3 μm to 0.04 μm. After ultrasonic vibration hybrid lapping, the pits and bulges on the surface of the optical glass are effectively removed, the surface roughness value decreases rapidly, and the surface morphology is uniform and flat.