Laser remanufacturing technology will encounter many kind of parts with complex curved surface in the actual processing. Reasonable laser path planning is the key factor to obtain high-performance metallurgical cladding. The plane space was divided into positive and negative domains by translating the current beam vector to a certain distance. The feature partition was used to judge the relationship between the current point set and rapidly eliminate the interference between laser beam and parts. For accurate detection, the interference factor λ was calculated to determine the vector h, divide the surface into regular micro-objects (block) and analyze the intersection information between the beam and the block to complete the accurate search of interference detection. The interferences ? was calculated under the condition of ideal cladding layer. With the current point as the focus and the tangent direction as the fixed axis rotation angle ?, the beam attitude was adjusted to the safe area. The three-dimensional model of parts was established and the trajectory was simulated by C program. The expected set of points was 47 883 of which 7341 were failure points, and the interferences were in the range of 10°. The effective correction of all interference beams was completed to generate the optimized robot path program. Collision detection between objects is executed by simulation experiments in the pre-processing stage, which eliminates potential safety hazards in laser remanufacturing in time, forms reasonable cladding trajectory, improves processing efficiency and saves production costs.