The work aims to illustrate the tribocorrosion behavior of 304 stainless steel in artificial seawater and the damage mechanism under mechano-electrochemical coupling, so as to provide theoretical support for development and utilization of marine equipment in the marine service environment. The tribological properties and electrochemical properties as well as the tribocorrosion behaviors of 304 stainless steel in artificial seawater were studied by tribocorrosion tester. The worn surface was characterized and analyzed by scanning electron microscopy, X-Ray diffraction and laser scanning confocal microscopy. Under load, the corrosion potential of 304 stainless steel changed from -0.310 V to -0.368 V at static corrosion; and the corrosion current density also increased by almost an order of magnitude. The friction coefficient of the 304 stainless steel and Al2O3 ceramic ball friction pair at the anode constant potential was smaller than that at the cathodic protection. When the load was 5 N, the corrosion wear rate of 304 stainless steel was 0.195 mm3/d, among which, the accelerated wear rate of corrosion accounted for 68.7%. When the load was 15 N, the total wear rate increased obviously, and the pure wear rate accounted for the largest proportion, namely 60.1% and the corrosion accelerated wear rate accounted for 39.1%. The corrosion wear behavior of 304 stainless steel is a dynamic process of "mechanical depassivation - chemical repassivation". There is a clear interaction between the corrosion and wear processes. During the wear process, martensite transformation occurs on the surface of 304 stainless steel, and the corrosion is further strengthened by galvanic corrosion. At the same time, the reaction product of the corrosion process reduces the wear resistance of 304 stainless steel. As the load increases, the corrosion accelerated wear rate that contributes the most to the total corrosion wear rate gradually changes to the pure wear rate, and the load has a greater influence on the mechanical wear of 304 stainless steel.