The work aims to fabricate Ni-based composite coating on Ti811 titanium alloy surface by laser cladding technology for the improvement of its friction and wear properties. The Ni45+WC+Y2O3 multi-track cladding layer was prepared on the surface of Ti811 titanium alloy by coaxial powder feeding laser cladding technology. The microstructure and phase composition of the cladding layer were analyzed by XRD, SEM and EDS; and the Bramfitt two-dimensional lattice mismatch theory was applied to calculate the two-dimensional misfit between low-index crystal planes to analyze the structure of composite phase. The microhardness of the cladding layer was examined by microhardness tester and the friction and wear properties of substrates and cladding layer by friction-wear tester. The wear volume of the substrate and cladding layer was measured by white light non-contact profiler; the friction along with the wear mechanism of cladding layer was analyzed based on the wear surface morphology. The results showed that the formation phases of the cladding layer mainly contained Ti2Ni, TiB2, TiC, α-Ti and a composite growth phase in which TiC was dependent on TiB2, and the two-dimensional misfit degree of TiC (111) and TiB2 (0001) crystal planes that was influenced by the thermal expansion was δ=0.907%, meeting the lattice interface coherent principle, indicating that TiB2 can work as the heterogeneous nucleation nucleus for the growth of TiC. The microhardness, friction coefficient, wear volume, wear rate of the cladding layer were about 1050~1100 HV0.5, 0.42, 4.07 ×107 μm3, and 3.0×10–4 mm3/(N?m), respectively. The wear mechanism of the cladding layer was found to be a mixed wear mechanism of abrasive wear as the main and adhesive wear as the auxiliary. Compared with those of the substrate, the microhardness of the cladding layer is improved by 2.5 times; the friction coefficient and wear rate are decreases by 35% and 36%, respectively; the friction and wear properties of the cladding layer are increased significantly.