The work aims to prepare ceramic reinforced composite wear-resistant coating on titanium alloy. In-situ self-generated TiB2, TiC and CrB ceramic reinforced Ni-based wear-resistant coatings were fabricated on Ti6Al4V by plasma arc cladding. X-ray diffractometer, scanning electron microscopy, energy dispersive spectroscopy and microhardness tester were used to characterize and test the phase composition, microstructure, chemical components in micro zone and mircohardness of the coating. Microstructure of the area nearby the fusion line consisted of Ni-Ti dendrites and eutectic phase dispersed between dendrites. A large amount of in situ reinforcing phase in the middle and upper part of the coating distributed in the Ni-based solid solution matrix. TiB2 and TiC reinforcing phases were formed by the in situ reaction between B and C elements from the melted titanium base metal and the cladding powder; while CrB reinforcing phase was formed by the reaction of Cr and B elements from the Ni-based cladding powder. Morphology of the reinforcing phase was determined by the combination of crystal structure and thermodynamic and kinetic condition of the cladding pool. Therefore, the microhardness of the coating increased apparently with the highest value of 1037HV0.2. By the plasma cladding technology, in-situ self-generated TiB2, TiC and CrB ceramic reinforced Ni-based wear-resistant coatings can be prepared on titanium alloy with in situ metallurgical reaction of Ni-Cr-Ti-B-C system in bath. Compared with Ti6Al4V, the microhardness of the coating increases significantly due to the presence of massive reinforcing phase dispersed in the Ni-based solid solution matrix.