The paper aims to study the influence of processing parameters on the surface skewness and kurtosis of the parts. The single-factor experiment scheme was used to mill Cr12MoV die steel. The three-dimensional surface profiler was used to collect the three-dimensional topography of the workpiece surface under different conditions, and the three-dimensional surface skewness and kurtosis were measured to analyze the reasons of surface topography changes. The results showed that with the increase of cutting speed, the skewness value first increased and then decreased; and the kurtosis value first decreased and then increased. When the cutting speed was 197 m/min, the skewness value was －0.21; the kurtosis value was 2.62; and the surface topography was flat. With the increase of feed rate, the skewness value gradually increased from a negative value to a positive value; and the kurtosis value decreased first and then increased. When the feed rate was 0.25 mm/r, the skewness value was positive; and the kurtosis value reached to 4.17. With the increase of cutting depth, the skewness value increased gradually; and the kurtosis value decreased first and then increased; but the surface topography changed little. With the increase of row distances, the skewness value and the kurtosis value both increased first and then decreased, which had a greater influence on the surface topography. When the row distance was small, the surface contour amplitude distribution was more uniform. With the increase of the cutter radius, the skewness value and the kurtosis value increased gradually. When the cutter radius was 5 mm, the minimum skewness value was –0.11; the minimum kurtosis value was 1.93; and the processing surface finish was better. Increasing the use of skewness and kurtosis can make the appearance of the processed surface more comprehensive. Studying the influence of cutting parameters on the three-dimensional skewness and kurtosis of the machined surface can provide a theoretical reference for optimizing the cutting parameters of plastic mold milling.