The work aims to analyze the application prospect of titanium-based IrO2-Ta2O5 oxide electrodes in the electrolyte containing fluorine. The titanium-based Ir-Ta oxide electrodes were prepared by thermal decomposition. The effect of fluorine on morphology of titanium-based IrO2-Ta2O5 oxide electrodes was analyzed via scanning electron microscopy. The effect of fluorine on electrocatalysis of IrO2-Ta2O5 mixed oxide electrodes in H2SO4 solution was also studied by cyclic voltammetry, stable polarization, and electrochemical impedance spectroscopy. Based on experiment results, the cracks appeared in the IrO2-Ta2O5 mixed oxide electrodes after accelerated electrolysis at 2 A/cm2 for 72 h when fluorine content was higher than 5 mg/L, and the size and amount of crack increased with increasing fluorine content. When fluorine content was below 10 mg/L, it had little influence on CV feature of IrO2-Ta2O5 mixed oxide electrodes during accelerated electrolysis for 72 h, but fluorine content of 10 mg/L lead to increase of cyclic voltammetry area by 24%. Fluorine could increase potential of oxygen evolution and charge transfer resistance, and reduce the double layer capacitance. Fluorine in the electrolyte may accelerate the failure of titanium-based Ir-Ta oxide electrodes. Although fluorine can improve the surface roughness and electrocatalytic performance of the electrodes, the electrocatalytic property of the electrode for oxygen evolution decreases in view of high dissolution of iridium oxide of the electrodes. Titanium-based IrO2-Ta2O5 mixed oxide electrodes have application prospect in acidic electrolyte with fluorine content less than 5 mg/L.