The work aims to treat the TiN/MT-TiCN/Al2O3/TiOCN multilayer coatings through micro-blasting and study the effect of micro-blasting post-treatment on the friction and wear properties of coatings. Multilayer coatings were deposited on cemented carbides by chemical vapor deposition (CVD). X-ray diffraction (XRD) and scanning electron microscopy (SEM) were applied to characterize the microstructure of coatings. The hardness, stress and adhesion strength of coatings were tested by mi-crohardness tester, nanoindentation, X-ray stress tester and scratch tester. The friction and wear properties of coatings were investigated by UMT-3MT tribometer. After micro-blasting treatment, the roughness of TiN/MT-TiCN/Al2O3/TiOCN multilayer coating was improved, the micro-hardness increased by 21.4% and the nano-hardness of TiOCN layer increased from 36.31 GPa to 39.32 GPa. Meanwhile, the friction coefficient decreased, the wear volume increased from 1.95×10-3 mm3 to 2.26×10-3 mm3 and the wear rate increased from 1.81×10-6 mm3/(N?m) to 2.10×10-6 mm3/(N?m). Micro-blasting post-treatment improved the hardness of TiOCN top layer, but reduced the thickness of TiOCN top layer. Moreover, many obvious cracks were formed on the surface of TiOCN layer, and the plastic resistance of Al2O3 layer became weak. Therefore, the TiOCN layer was worn out in advance, and a large amount of debris were produced on the Al2O3 layer. Consequently, the wear was aggravated and the coating showed poor wear property after micro-blasting. The micro-blasting treatment can effectively improve the mechanical properties of TiN/MT-TiCN/Al2O3/TiOCN coatings. However, the cracking and thinning caused by micro-blasting treatment reduce the wear resistance of the TiN/MT-TiCN/Al2O3/TiOCN multilayer coatings when coatings are thinner.