The corrosion fatigue of biomedical metallic alloys were summarized. This paper summarized the harmfulness, classification, design and control of the corrosion fatigue of biomedical metals for medical application. The current research status of the corrosion fatigue of biomedical metals were reviewed, and the future research and development in interdisciplinary research and new materials of the corrosion fatigue were proposed. Corrosion fatigue usually initiated from the surface which was relative with the lifespan of the implants. The corrosion fatigue was distributed into three types. Environment should be considered for the design of the research of corrosion fatigue study. Surface modification and alloying can be used to improve the corrosion fatigue properties of the metals. Many problems need to be solved. The corrosion fatigue behavior and the mechanism of microbiologically influenced corrosion should be elucidated. Microbiologically influenced corrosion fatigue is a long and complex process. The rea-sonable three-dimensional finite element dynamical analysis models should be combined with the experiments to guide the design of implants. The fundamental data especially the corrosion fatigue related data of many new alloys is still unknown. Much work should be done to ensure the safety of the new metals in service.