The work aims to study the effect of Sr/Sn on the mechanical and bio-corrosion properties of rapidly solidified MgZnCaMn alloys. The effects of Sr/Sn on the structure, microstructure, thermal properties, room temperature strength, plastic deformation and in vitro degradation of MgZnCaMn alloys were investigated by X-ray diffraction, scanning electron microscopy, differential thermal analysis, universal capacity test machine, static immersion and electrochemical testing, respectively. After the addition of Sr element, the amount of amorphous phase in MgZnCaMn alloy increased, and the amount of hydrogen evolution in Mg64.7Zn30Ca4Mn0.8Sr0.5 alloy decreased significantly. The self-corrosion current density was 1.61×10?4 A/cm2, the average corrosion rate was 0.35 mm/a, the compressive strength was 621 MPa and the plastic compressive strain was 0.8%. After the addition of Sn element, the amorphous phase in the MgZnCaMn alloy disappeared almost completely. The snow-like Mg2Sn phase and MnZn13 phase were the main phases in the alloy. The hydrogen evolution of the alloy had no significant change. The self-corrosion current density were at magnitude of 10?4, the compressive strength was 412 MPa, and the compressive plastic strain was 1.6%. The addition of Sr can improve the amorphous forming ability of MgZnCaMn alloy, increase the volume fraction of amorphous phase, and improve the strength and corrosion performance of the alloy. The addition of Sn element reduces the amorphous forming ability of MgZnCaMn alloy. The alloy is mainly composed of ductile phase, and its room temperature plasticity is obviously improved. Compared with the initial alloy, the corrosion resistance reduces slightly, but it is still superior to conventional biomedical magnesium. Alloys (such as high-purity magnesium Mg, Mg-Zn-Ca, etc.) have good corrosion resistance.