The work aims to study the influence laws and main influence factors of high pressure fracturing fluid to JY-50 fracturing bend pipe in the process of hydraulic fracturing operation. Based on the liquid-solid two-phase flow theory and FLUENT erosion model, the FLUENT software was used for 3 times to repeat analysis and take the average to eliminate the error and obtain the effects of proppant density, particle size, mass concentration and change of fluid velocity on bend pipe erosion behavior. The easy erosion area of fracturing bend pipe was the curved section near the exit of the inner wall of the lateral area and close to the straight tube of bend pipe export area. As proppant density and particle size increased, the maximum erosion rate increased. When the density of proppant increased from 2500 kg/m3 to 3500 kg/m3, the maximum erosion rate increased by 0.69 times. When diameter changed from 0.074 to 0.54 mm, the maximum erosion rate increased by 1.45 times, but the impact on the average erosion rate value was not obvious. The increasing proppant concentration led to the approximately linear increase of erosion rate. When the proppant concentration changed from 40 kg/m3 to 210 kg/m3, the maximum erosion rate increased by 2.3 times and the average erosion rate increased by 1.526 times. When velocity ranged from 5 m/s to 25 m/s, the maximum erosion rate and the average erosion rate increased by 34.30 and 34.85 times, respectively. Through the numerical simulation for erosion behavior and effects on JY-50 pressure fracturing pipe, the erosion laws of pressure fracturing fluid parameters on pressure frac-turing bend are obtained. Combined with the maximum erosion rate, average erosion numerical value and growth times analysis, fracturing fluid flow rate is the main factor for erosion rate growth and significantly affects the erosion wear of bend.