The work aims to prepare the superamphiphobic coatings with good mechanical and chemical stabilities. Three sizes of micro-/nanometer silicas and epoxy resin were constructed to the concave-convex micro-/nanometer rough structure. After the monolayer of low-surface-energy ?uoride-chains was modified on concave-convex micro-/nanometer rough structure, the superamphiphobic coating was prepared. FESEM, AFM and XPS were used to analyze the morphology and composition of coating surface. The contact angle and roll angle of coating surface were tested by the contact angle meter. Then, abrasive paper friction test, chemical resistance test and solvent resistance test were carried out to evaluate the wear resistance and chemical stability of the superamphiphobic coating. The coating had outstanding superhydrophobic properties to liquids with different surface tension in the range of 34~72 mN/m, such as water, ethanediol and peanut oil. After 5 cycles of mechanical friction on abrasive paper, the contact angle (CA) of peanut oil was above 155? and the rolling angle (RA) was below 5?. As for ethylene glycol and water, CAs and RAs were above 154? and below 2.5? respectively after 10 cycles of mechanical friction. In addition, the coating remained superhydrophobic to water and ethylene glycol after being immersed in an alkali solution (pH=14) and n-heptane for 168 hours. After 96 hours, the contact angle of the coating with peanut oil was above 153?, and the rolling angle was between 10? to 20?. The coating has great potential application value in the industrial field for its excellent superamphiphobic properties and good mechanical and chemical stability.