The work aims to design MoS2/Pb-Ti multilayer films and improve tribological properties in vacuum and air. MoS2/Pb-Ti multilayer films were deposited by magnetron sputtering technology. The surface morphology, microstructure, me-chanical properties, vacuum and atmospheric tribological properties of the MoS2/Pb-Ti multilayer films were evaluated by scanning electron microscopy (SEM), X-ray diffraction (XRD), nanoindenter, vacuum and atmospheric tribological tests, respectively. Optical microscope, energy dispersive spectrometer (EDS), and Raman spectrometer were used to analyze wear tracks and scars. As the thickness of MoS2 layer increased, the surface of MoS2/Pb-Ti multilayer film gradually refined and became much smoother. Meanwhile, the microstructure changed from the metal phase to the MoS2 phase-dominated structure. The elastic modulus of MoS2/Pb-Ti multilayer films decreased gradually with the increase in MoS2 layer, while the hardness increased first and then decreased. In vacuum, the friction coefficient of MoS2/Pb-Ti multilayer film was as low as 0.01, and the wear rate was as low as 2.2×10?7 mm3/(N?m). In air, the friction coefficient was as low as 0.07, and the wear rate was as low as 2.7×10?7 mm3/(N?m). In vacuum, when the thickness of MoS2 layer was too thin, the wear mechanism of MoS2/Pb-Ti multilayer film was adhesive wear. The increase in the thickness of MoS2 layer contributed to forming a stable transfer film, leading to significantly reduced friction and wear. In air environment, Ti protected the structure of MoS2 from the attack of H2O and O2, resulting in low and stable friction and wear.