The work aims to prepare in-situ carbide enhanced high-entropy alloy-based cladding layers, study the microstructure and properties of the cladding layers, and then provide the experimental example and theoretical basis for further application of high-entropy alloys and their composites in surface engineering. In-situ VC reinforced CoCrCuFeNiMn(VC)x (x=0, 0.1, 0.2, mole ratio) high-entropy alloys cladding layers were prepared on Q235 steel substrate by plasma cladding. Phase composition, microstructure and microhardness of the cladding layers were investigated by XRD, OM, SEM, TEM and microhardness tester. CoCrCuFeNiMn(VC)x (x=0.1, 0.2) cladding layers were composed of solid solution matrix phase(FCC1+FCC2) and VC enhanced phase. VC was in granular or petaloid shape and mostly deposited in the interdendrite and only a small amount was precipitated in the dendrite. From TEM results, the interface between in-situ synthesized VC and substrate was clean without any other reacting products and conformed to the interface characteristics of the in-situ composite material. In a certain region of (x=0~0.2), the microhardness of cladding layers increased as the VC content went up. In-situ synthesized VC reinforced CoCrCuFeNiMn high-entropy alloy-based coatings can be prepared on Q235 steel substrate by plasma cladding. Cladding layers have a good metallurgical combination with the substrate and in-situ VC plays a significant role in strengthening cladding layers.