The work aims to study the effects of glass molding parameters on profile deviation of aspherical glass lenses. Orthogonal test was designed, numerical model of the glass lens molding process was established through Msc.Marc software. The deviation of lens profile was measured in different combinations of molding parameters so as to obtain the optimum combination of molding parameters. Then molding test was applied to the lens, the deviation between finished lens shape and design value was observed to verify simulation analysis results. According to orthogonal optimization analysis, average value of the maximum profile deviation was 2.876 μm at the molding temperature of 570 ℃, 2.808 μm at the molding rate of 0.02 mm/s, 2.780 μm at the friction coefficient of 0.6, 1.893 μm at the annealing rate of 1.5 ℃/s, 1.775 μm at the constant pressure of 700 N, and 1.990 μm at the cooling rate of 1 ℃/s. All of them were the minimum in corresponding group of parameters. The optimum combination of modeling parameters was as follows: molding temperature as 570 ℃, molding rate as 0.02 mm/s, friction factor as 0.6, grid size as 0.05 mm, annealing rate as 1.5 ℃/s, dwell pressure as 700 N and cooling rate as 3 ℃/s. The maximum deviation measured in molding test was 1.61 μm. The farther it is from the lens center, the larger the profile deviation of the lens surface is. The finer meshes can more accurately simulate glass molding process. The lens profile deviation will increase with the increase of molding rate, and decrease with the increase of molding temperature. However, the profile deviation will increase if the molding temperature is over-high, and the profile deviation will decrease with the increase of annealing rate, dwell pressure and friction coefficient. Cooling rate has no significant effect on profile deviation.