The work aims to study optimum process parameters of laser cladding Ni60-25%WC coating on U71Mn steel surface. First, single-channel single-factor test was performed to preliminarily select four process parameters, namely, laser power (A), powder feeding rate (B), scanning speed (C) and spot diameter (D). Then, single-channel orthogonal test involving 4 factors and 3 levels was completed. Range analysis was done with cladding layer width, height and dilution ratio as criteria of cladding layer quality. Finally, optimum process parameters were obtained, microhardness and microstructure of the cladding layer were analyzed. The process parameters obtained from the single-channel single-factor test were: A=1500 W, B=4 g/min, C=6 mm/s and D=2.2 mm. The optimum process parameters by single channel orthogonal experiment showed that A=1500 W, B=4 g/min, C=6 mm/s, D=2.2 mm; the range analysis showed that degree of effect of process parameters on quality criteria was different. For effect on cladding layer width, the order was C>B>A>D; for effect on cladding layer height, B>C>D>A; and for effect on dilution ratio of cladding layer, B>D>C>A. Comparison showed that powder feeding rate was the dominating impact factor of cladding layer. The microhardness of cladding layer was up to 1170HV, which was 3.7 times of that of substrate. A smooth and closely-bonded cladding layer can be prepared, and surface hardness is increased obviously by laser cladding Ni60-25%WC coating on U71Mn steel surface.