The work aims to improve usability and corrosion resistance of 45 steel. With 316L stainless steel powder as cladding material, stainless steel cladding layer was prepared on the surface of annealed 45 steel. CCD center combination design was adopted. Geometrical morphology parameters of the cladding layer was detected in metallographic method. Microstructure of the cladding layer was analyzed with optical microscopy (OM) and scanning electron microscopy (SEM). Microhardness and wear resistance of the cladding layer were measured with microhardness tester and wear tester. Corrosion resistance of the cladding layer was tested based upon polarization curve. The cladding layer exhibited metallurgical bonding to the substrate provided with laser power of 600 W, scanning speed of 22.5 mm/s, powder feeding rate of 0.18 r/min. Hardness of the cladding layer was 461.3~559.8HV, about 2 times that of the substrate; abrasion loss of the cladding layer was 0.0146 g, 0.1 times that of the substrate; friction coefficient was relatively stable and kept at 0.5, about 0.3 times that of the substrate self-corrosion current density was 3.274×10?7 A/cm2, 0.7 times that of the substrate. Laser cladding of 316L stainless steel coatings on annealed 45 steel can effectively improve wear resistance and corrosion resistance of the coatings.