The work aims to study rule and mechanism of influence of normal load and speed on dry friction behavior by using Mg59.5Cu22.9Ag6.6Gd11 Mg-based bulk metallic glass (BMG), and provide an experimental basis for further studies of BMG. Friction and wear experiments were performed by changing normal load and sliding speed with UMT-2 multifunctional friction and wear machine. Width and depth of wear tracks were measured with white light interferometry, and wear volume and wear rate were calculated according to formula. Wear tracks were analyzed with scanning electron microscopy and EDS energy spectrum, and wear mechanism of BMG was exposed. With the increase of load, the wear rate first decreased and then remained stable, and friction coefficient decreased slightly. With the increase of sliding speed, the wear rate first decreased and then increased, and the minimum value appeared at the relative sliding speed of 120 mm/s. When the load was less than 20 N, the grinding crack surface was covered with furrows and small granular debris. When the load was greater than 20 N, inhomogeneous overlapped plastic deformation layer appeared on the surface of BMG, and the friction ball head was apparently glued with transferred thick and sticky film. When the sliding speed was low, the grinding crack surface was covered with furrows. As the speed increased, the surface was subject to softening and uniform rheology, followed by melting and spalling at low load. Wear mode of the BMG is abrasive wear accompanied by oxidation and slight adhesion at low load, and mainly adhesive wear at the load of over 20 N. The wear mode is mainly abrasive wear at low sliding speed, and combined spalling and abrasive wear (melting failure) at the sliding speed of 180 mm/s.