The work aims to prepare high performance self-polishing (SP) antifouling paints based on silicone acrylate copolymer. A silicone acrylate copolymer was synthesized. With functional silicone acrylate copolymer as matrix and cuprous oxide as major antifouling agent, self-polishing antifouling paints were prepared. The polymer was analyzed with Fourier transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). Abrasion rate, static antifouling property, freshwater resistance, physical and mechanical properties, and drag-reducing property of the antifouling paints was analyzed by performing laboratory dynamic abrasion experiment, deep-sea hanging panel experiment, freshwater immersion experiment, physical and mechanical properties test and drag-reducing property test, respectively. For the selected antifouling paint made in excellent formula, the polishing rate was 5 μm/month, antifouling property continued for 26 months, freshwater immersion resistance continued for 2 months, physical and mechanical properties were excellent, and resistance-reducing ratio was up to 4%. The as-deposited self-polishing (SP) antifouling paints based on silicone acrylate copolymer have excellent antifouling property, physical and mechanical properties, freshwater immersion resistance and remarkable drag-reducing property, hence the paints are a kind of high performance self-polishing antifouling paint.