This work aims to obtain a marine environment-friendly copper-free antifouling paint formula which rivals traditional copper antifouling paint. Environment-friendly antifoulant conforming to the technical demand of copper-free paint was selected firstly, coating formula was studied to obtain the optimal formula of environment-friendly copper-free antifouling paint. The two different antifoulants compounding copper-free self-polishing antifouling paint meet the evaluation standard of mid-potency antifouling paint, and can rival the 3 years potency traditional copper antifouling paint. Formula of the two groups is Econea/Dcoit and Econea/ZnPT, respectively. For the antifoulant being compounded by the 2 antifoulants with mass ratio of 1:1, the practical antifouling effect is 1+1＞2. These two antifoulants have good practical anti-fouling effect and exhibit excellent environmental friendliness as they can degrade rapidly in seawater. The optimum formula content of acrylic zinc resin is 40%～50% (wet weight) in mid-potency antifouling paint in the copper-free antifouling paint formulation system. Various properties of the environment-friendly copper-free antifouling paint were good. The paint had broad spectrum, high efficiency and excellent antifouling effect.