The work aims to research the effects of different constant potentials on the tribocorrosion behaviors of Monel400 alloy in seawater. The samples were processed into cylindrical samples and clamped by the special fixtures designed. The abrasion experiment under various constant potentials was carried out by friction testing machine and electrochemical workstation. The electrochemical performance of the alloy was evaluated based on the change in the open-circuit potential polarization curve. The friction property of the alloy was evaluated based on the change in the abrasion loss. The wear mechanism was revealed by scanning electron microscope and the interaction mechanism was discussed. The open-circuit potential in the friction process was lower than that in the static corrosion. As the applied potential increased, the corrosion current density increased, the friction coefficient decreased and the total volume loss increased. The corrosion and wear had obvious interaction. The friction can damage the passive film of the alloy surface, causing the new surface with higher electrochemical activity to be exposed to the solution; therefore, the surface corrosion is accelerated. The corrosive product layer generated by the corrosion is quite coarse and loose. Its shear strength is much lower than that of the base metal alloy. Therefore, when alumina block slides across the alloy surface, such layer is easily peeled off, finally resulting in the acceleration of material loss. The loss amount of materials under corrosion and wear is apparently higher than that under the pure wear.