This work aims to obtain a multifunctional nano-coating material with antibacterial, antimildew, anti-corrosive and flame-retardant functions for comprehensive protection of marine and aerospace equipment depending on synergistic effect of special functional nano-particles and reasonable ancillary use of different functional coatings. Anticorrosive primer was prepared by adding zinc polyphosphate and graphene as compound agents into substrate resin taking epoxy resin as primer and intermediate paint. Antibacterial, antimildew and anti-corrosive polyurethane finish paint was prepared by adding zinc pyrithione, nano-silver antimildew compound agents and nano ceramic particle wear-resistant additive into the substrate resin taking acrylic acid-modified polyurethane as finish paint. The multi-functional integrative protective coating material was prepared by matching anti-corrosive primer, flame-retardant intermediate paint as well as antibacterial, antimildew and anti-corrosive finish paint in a reasonable manner. Conventional properties of the nano-coating were evaluated by performing pencil hardness test, cross cut adhesion test, impact strength test and artificial aging resistance test. Corrosion resistance was studied by performing salt spray test. Flame retardancy was studied by performing combustion experiment. Antibacterial and antimildew properties were investigated by performing antifungal and antibacterial experiments. Hardness of the nano-coating was up to H, adhesive force reached grade 0 and impact resistance was 50 kg?cm. After artificial aging for 800 h, the paint film changed slightly. After the neutral salt spray test, the substrate had no corrosion spot. 12 s vertical ignition test showed that the burning length was merely 1 mm and drip afterflame time was 0 s and the burn length only 1 mm. Smoke density study showed the average Dm was only 13 for 240 s. Bacteriostasis rate of the nano-coating was up to 99% and antimildew grade was grade 0. Wear resistance test showed that mass loss of the coating was 32 mg. The integrative nano-coating prepared as-developed exhibits excellent antibacterial, antimildew, anti-corrosive and flame-retardant properties, hence it plays an important role in protecting special equipment such as space aircraft and marine facilities.