The work aims to provide theoretical support for filler selection and application to building-energy saving coating by studying effects of reflective, insulating and radiant fillers on reflective/thermal insulation performance of building energy-saving coating. The reflective, insulating and radiant building-energy saving paints were prepared by mixing rutile titanium dioxide, hollow glass bead and far infrared ceramic powder with styrene-acrylic emulsion, respectively. Properties of the coatings were characterized by using scanning electron microscope, ultraviolet/visible/near-infrared spectrophotometer, heat conductivity coefficient measuring instrument and infrared emittance measurement instrument. Effects of content and average grain size of the fillers on reflective/thermal insulation performance of the coating were investigated. Optimal content (percentage accounts for total mass of film forming material) and average grain size of rutile titanium dioxide, hollow glass bead and far infrared ceramic powder were 25% and 0.25 μm, 9% and 325 mesh, 9% and 1 μm, respectively. Meanwhile, average solar reflectance, heat conductivity coefficient and infrared emittance in 8~14 μm band of corresponding coating was 85.88%, 0.05 W/(m?K) and 0.91, respectively. Excellent thermal insulation performance was obtained. Thermal insulation performance of building energy-saving coating is affected by both content and average grain size of filler, hence both shall be selected as required during actual application.