To study the corrosion resistance, analyze the corrosion mechanism and failure mechanism of Hastelloy C-276 alloy in brominated butyl rubber solution. Weight-loss method was performed and the corrosion environment of Br-rubber mixer in brominated butyl rubber production process was simulated to research the effects of temperature, liquid bromine content, water content and rotating speed, ect. on the corrosion of Hastelloy C-276 alloy. Then Scanning electron microscope (SEM) and X-ray diffraction (XRD) techniques were respectively applied to characterize the corrosion morphology and corrosion products. Obtained results reveal that NiBr2, FeBr2, MoBr2, CrBr2, etc. were main corrosion products of Hastelloy C-276 alloy in the bromine-containing corrosion solution. The corrosion rate of Hastelloy C-276 alloy increased with temperature, water content, liquid bromine content and the rotating speed increase, which play important roles in Hastelloy C-276 alloy corrosion The corrosion mainly occurs in the form of general corrosion accompanied with intergranular corrosion. It is concluded that severe electrochemical corrosion of Hastelloy C-276 alloy happens in brominated butyl rubber environment and the increase of temperature, liquid bromine content, water content and rotating speed can obviously enhance the corrosion rate of Hastelloy C-276 alloy. Thus, Hastelloy C-276 alloy can not sever as the main material of Br-rubber mixer in the production of brominated butyl rubber.