The work aims to study mechanical property under synergistic effect of coating-substrate in different composition proportion by preparing multi-element nickel-based coatingon FV520B stainless steel substrate by adopting plasma cladding technology. Surface and interface morphology of the coatingswere observed byusing scanning electron microscope (SEM), tensile and high temperature compression property of the coating-substrate were tested. Tensile strength and high temperature deformation resistance of each coating were obtained. Influences of structure, phase distribution characteristics and coating composition on mechanical properties of the coating-substrate system were analyzed. Plasma cladded coatings featured in dense microstructure and good metallurgical bonding on interface, the bonding mode could improve comprehensive mechanical property of the coating-substrate; synergistic effectof the coating-substrate could improve tensile strength and deformation resistance significantly, and composition, structure and phase distribution characteristics of the coatingswere key factors influencing synergistic deformation behavior of the coating-substrate. The coating Ni60+20%Ti exhibited the best tensile strength, which was up to 921 MPa, 19.6% higher than that of substrate material. The coating Ni60+30%Ti+10%WC exhibited the best high temperature mechanical properties, the high temperature deformation resistance was up to 687.87 MPa. Tensile strength of the plasma claddedmulti-element nickel-based coating on the substrate improves, and the high temperature deformation resistance improves significantly.