Aloe mucilage solution featuring in good rheological property and biocompatibility is expected to be potential green lubricant. Firstly, fresh aloe mucilage was extracted as lubricant, and polysaccharide of aloe mucilage was analyzed with infrared spectrum. Tribological behavior of zirconia ceramic ball sliding against Co-Cr-Mo alloy provided with dry friction, water lubrication and aloe mucilage lubrication, respectively was studied on ball-on-disk frictional experiment apparatus. Tribological properties of the Co-Cr-Mo surfaces with different wettability were discussed preliminarily. Finally, morphology and element distribution of the worn surface were analyzed using with a scanning electron microscope and energy disperse spectroscopy. The wettability had obvious influence on tribological properties of Co-Cr-Mo surface. Provided with dry friction condition, average friction coefficient of hydrophobic surface was 0.65, lower than that of hydrophilic surface. Provided with water lubrication, the friction coefficient was 0.35, about 20% lower than that of hydrophilic surface. Provided with aloe mucilage lubrication, the friction coefficient reduced significantly to 0.28, less stable than that of hydrophilic surface. Provided with aloe mucilage lubrication, the alloy surface is subject to slight wear with main wear form of shallow furrow. The polysaccharide in aloe mucilage generates a transfer film during the friction process, which can lubricate and protect the Co-Cr-Mo alloy.