The work aims to improve the fretting wear resistance of titanium alloy surface. MoS2-Ti/Cu-Ni-In multilayer solid lubricating films were deposited on the surface of titanium alloy by non-balanced magnetron sputtering technique, and were compared with MoS2-Ti and Cu-Ni-In monolayer solid lubrication films. The morphology, hardness, fretting wear behavior and wear scar of solid lubrication films were analyzed by scanning electron microscope, micro hardness tester, friction wear tester and surface profile instrument. The prepared Cu-Ni-In and MoS2-Ti monolayer films structure was clear and had good adhesion to substrate. Alternating structure of MoS2-Ti/Cu-Ni-In multilayer films was clear and the structure was compact. The hardness of MoS2/Cu-Ni-In multilayer films was higher than that of MoS2-Ti and Cu-Ni-In monolayer films. Average fretting coefficient of MoS2-Ti/Cu-Ni-In multilayer films was 0.06, average fretting coefficient of MoS2-Ti monolayer films was 0.102 and average coefficient of Cu-Ni-In monolayer films was more than 1.0. After 12,000 fretting cycles, final wear amount of the MoS2-Ti/Cu-Ni-In multilayer films was 0.045 mm3, Cu-Ni-In monolayer films 37.79 mm3 and MoS2-Ti monolayer films 0.296 mm3. The fretting wear volume of multilayer films has improved by 2 orders of magnitude compared with that of Cu-Ni-In monolayer films, and by more than 5 times compared with that of MoS2-Ti monolayer films. Several interfaces in MoS2-Ti/Cu-Ni-In multilayer suppress growth of monolayer grain, thus refining monolayer grain in the alternating structure. The introduction of Cu-Ni-In films into the MoS2-Ti/Cu-Ni-In multilayer films delays peeling off and transfer of the MoS2-Ti films, and has enhanced the lubrication and anti-friction effect of the third body between stainless steel ball and the multilayer films. The multilayer films showed excellent fretting wear resistance.