The work aims to improve the service performance of the titanium alloy at high temperature and explore the influence of Cr2AlC MAX coating on the high-temperature oxidation behavior of TC4 titanium alloy. Highly purified Cr2AlC MAX coating was successfully prepared on TC4 titanium alloy by low temperature reaction DC magnetron sputtering combined with follow-up annealing treatment. The phase composition, morphology and ingredients of Cr2AlC coating specimen and TC4 titanium alloy before and after isothermal oxidation in air at 750 were investigated by XRD, SEM, EDS and raman spectro ℃ scopy. The analytical balance was employed to measure oxidation kinetic curve of oxidized TC4 titanium alloy and Cr2AlC coating specimen in static air at 750 ℃ . The results showed that nearly 13 μm thick flocculent Al2O3 and TiO2 mixture oxide filmwas formed on the surface of TC4 titanium alloy after isothermal oxidation at 750 in air for 10 h. However, a compact ℃ oxide film main consisting of α-(Al,Cr)2O3 was formed on the surface of Cr2AlC coating, it could prevent inward diffusion of oxygen element effectively. The oxidation weight gain of Cr2AlC coating specimen after isothermal oxidation at 750 in air ℃ for 90 h was only 6.6% of that of the uncoated TC4 titanium alloy after isothermal oxidation at 750 in air for 10 h. Cr ℃ 2AlC coating is provided with excellent high temperature oxidation resistance and can improve the operating temperature of TC4 titanium alloy significantly to reduce its rate of oxidation weight gain greatly.