The work aims to put forward the strategies to control the erosion and corrosion in the process of petroleum refining by analyzing the mechanism and influence factors of typical corrosion-erosion failures in refining equipment and system as the said failures are main potential troubles to the safe and stable operation of the refining units. Based on technological process of oil refining equipment, structural design of equipment and pipes, corrosive medium and materials, etc., the corrosion failures of impingement baffle in vacuum transfer line, reactor effluent pipeline at injection inlet of sulfuric acid alkylation unit, rich ammonium system in the top of sour water stripping tower, and tower wall in feeding zone of coking fractional column were respectively analyzed. The thinning of impingement baffle in vacuum transfer line eroded and corroded by naphthenic acid corrosion was avoided by the material upgraded to 317L. The sour water corrosion in rich ammonium system in the top of sour water stripping tower was prevented by the material upgraded to 316L and increasing the diameter of pipeline. The corrosion and leakage problem of tower wall in feeding zone of coking fractional column was solved by replacing the feeding distributor. The strategies to control the corrosion-erosion of the refining equipment: based on the concept of active anti-corrosion and selecting material by following the material selection guidelines, the possibility of corrosion in specific region should be evaluated by fully taking into account the actual technological operations of the equipment and pipelines. Once the major corrosion regions are found, relevant operation should be timely adjusted (operation processes, process anti-corrosion and corrosion monitoring, etc.), so as to ensure the safe and stable operation of the refining device.